Personality and dissociative experiences in smartphone users

The aim of this study was to explore the relationship between Problematic Smartphone Use (PSU), dissociative experiences and some characteristics of personality. The sample consisted of 400 Italian college students aged between 20 and 24 (M = 21.59, SD = 1.43). The materials included: a questionnaire on the use of smartphones, the Smartphone Addiction Scale (SAS-SV), the Dissociative Experience Scale (DES), and the Ten Item Personality Inventory (TIPI). Results showed that the college students in our sample used their smartphones mainly for messaging (50%), calling (42.5%), accessing the internet (38%), connecting via social networks (33.5%), taking photos (26.5%), gaming (8.5%) and using applications (.5%). According to the results of the SAS-SV, 70% of our sample showed PSU, without gender differences. Regarding the correlation with personality factors, intensive use of smartphones corresponds to lower emotional stability and the extraversion or 'energy' factor is predictive near the significance cut-off (p = .06), while among the dissociative experiences, passive influence and dissociative amnesia are the best predictors of smartphone addiction. The other variables are less significant (p = .07). The results underline the importance of detecting the PSU predictors in college students, in order to prevent psychopathological consequences

Tra affettività e diffidenza: un confronto tra le rappresentazioni sociali del cibo italiano e del cibo etnico

L’obiettivo di questo studio era di esplorare e mettere a confronto le rappresentazioni sociali del cibo italiano e del cibo etnico. A tale scopo, abbiamo coinvolto 74 italiani che hanno espresso la loro opinione relativamente alle due tipologie di cibo compilando un questionario a risposte aperte. I risultati indicano che la percezione del cibo italiano si fonda su concetti e categorie estremamente favorevoli, mentre, nella rappresentazione del cibo etnico, la sfiducia circa la sua salubrità sembra prevalere sull’attrattività esotica e sulle qualità organolettiche che pure gli vengono riconosciute. The aim of this study was to explore and compare the social representations of Italian and ethnic food. To this end, we involved 74 Italian participants who expressed their opinion on the two types of food in an open-ended questionnaire. The results indicate that the perception of Italian food is based on extremely favourable concepts and categories, while in the representation of ethnic food, mistrust about its wholesomeness seems to prevail over the exotic attractiveness and organoleptic qualities that are also recognized to it

Paura del COVID-19, creduloneria e cospirazionismo: differenze tra persone favorevoli e contrarie alla vaccinazione contro il COVID-19

Nel marzo 2020, la malattia da Coronavirus 2019 (COVID-19) è stata dichiarata pandemia globale dall’OMS. Tutto il mondo ha iniziato a progettare un piano vaccinale per porre fine al COVID-19. In Italia, il Decreto-Legge del 24 marzo 2022 ha reso obbligatorio il vaccino contro il COVID-19 per alcune categorie, ma, nonostante ciò, parecchie persone hanno comunque deciso di non vaccinarsi. Lo scopo dello studio è stato quello di esplorare le differenze nella paura del COVID-19, nella creduloneria e nelle convinzioni cospiratorie, in persone favorevoli e contrarie alla vaccinazione contro il COVID-19. I risultati hanno mostrato che le persone disposte a vaccinarsi contro il COVID-19 sembrano essere più credulone e mostrano maggiore paura del COVID- 19. Le persone contrarie alla vaccinazione per il COVID-19, invece, sembrano avere maggiori credenze cospiratorie sui vaccini. In March 2020, Coronavirus Disease 2019 (COVID-19) was declared a global pandemic by WHO. The whole world began to design a vaccine plan to end COVID-19. In Italy, the Decree-Law of March 24, 2022, made the COVID-19 vaccine mandatory for some categories, but despite this, several people still decided not to vaccinate. The purpose of the study was to explore the differences in COVID-19 fear, gullibility, and conspiracy beliefs in people in favor and against vaccination for COVID-19. The results showed that people willing to vaccinate against COVID-19 appear to be more gullible and show greater fear of COVID-19. People opposed to vaccination for COVID-19, on the other hand, seem to have more conspiracy beliefs about vaccines

Type 2 diabetes and cancer: problems and suggestions for best patient management

Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity and heterogeneity of these pathologies but also for the lack of standardised clinical guidelines. The diagnosis of cancer is traumatizing and monopolizes the attention of both patients and caregivers. Thus, pre-existent or new-onset diabetes can be overshadowed thus increasing the risk for short- and long-term adverse events. Moreover, drugs used for each disease can interfere with the clinical course of the concomitant disease, making challenging the management of these patients. Over the years, this issue has become more relevant because of the increased patients' life expectancy due to the improved efficacy of diabetes and cancer therapies. The purpose of this review is to highlight what is known and what should be taken into consideration to optimise the clinical management of patients with diabetes and cancer. Due to the complexity of these diseases, a multidisciplinary, shared approach, including all the protagonists involved, is necessary to improve patients' quality of life and lifespan

Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis

We carried out a prospective observational study to evaluate whether Monocyte Distribution Width (MDW) may play a role in identifying patients with sepsis in comparison with Procalcitonin (PCT). We prospectively enrolled all consecutive patients hospitalized at the Infectious Diseases Unit of Pescara General Hospital for bacterial infection or sepsis. MDW values were collected for all patients. Clinical characteristics, demographic data, past and present medical history, microbiological results, PCT, as well as neutrophil and monocytes indices at entry were compared in the 2 groups. Two-hundred-sixty patients were enrolled, 63.5% males, aged 59.1±19.5 years. Sepsis was diagnosed in 105 (40.4%); in 60 (57.1%) at least 1 microorganism was isolated from blood cultures. In multivariate models, MDW as a continuous variable (OR:1.57 for each unit increase; 95%CI: 1.31-1.87, p<0.001) and PCT˃1 ng/mL (OR: 48.5; 95%CI: 14.7-160.1, p<0.001) were independently associated with sepsis. Statistical best cut points associated with sepsis were 22.0 for MDW and 1.0 ng/mL for PCT whereas MDW values<20 were invariably associated with negative blood cultures. At ROC curve analysis, the AUC of MDW (0.87) was nearly overlapping that of PCT (0.88). Our data suggest that incorporating MDW within current routine WBC counts and indices may be of remarkable use for detection of sepsis. Further research is warranted

Relations Between Mood States and Eating Behavior During COVID-19 Pandemic in a Sample of Italian College Students

The fear of contagion during the COVID-19 pandemic has been indicated as a relevant cause of psychological pathologies occurring in this period. Food represents a compensating experience, distracting from the experiences of uncertainty, fear and despair, causing alterations in eating habits and behaviors. The study aims at evaluating the relations between fear of a pandemic, mood states and eating disorders in Italian college students, taking into account gender differences. During the lockdown for the pandemic, a sample of 469 college students equally distributed by gender, was recruited online using a questionnaire including the FCV-19S for the assessment of fear of COVID-19, the profile of mood states (POMS) for the evaluation of different emotional states, the eating disorder inventory-2 (EDI-2) and the binge eating scale (BES) to evaluate the presence of the levels of eating disorders. As expected, all emotive states measured by POMS (tension, depression, anger, tiredness, confusion) resulted significantly correlated with the fear of COVID-19. Women were more exposed to fear of COVID-19 showing greater tension, fatigue, depression and confusion, and a significantly higher total mood disturbance score than males. Regarding the EDI-2 and BES variables, tension and anxiety resulted significantly correlated also with bulimic behavior, while depression with interoceptive awareness, impulsivity, and binge eating behaviors, without gender differences. In conclusion, the negative impact of the fear of COVID-19 on the emotional profile and eating behavior suggests the need to implement strategies against psychological distress during the pandemic emergency, and to design psycho-educational interventions aimed at modifying the lifestyle for preventing risks of mental disorders fostering health-oriented behaviors

Early administration of the phytoestrogen genistein induces sex specific permanent alterations of nitrergic and vasopressinergic systems

Soy foods contain phytoestrogens as genistein (GEN) which may interfere with endocrine system and, during developmental critical periods, lead to permanent alterations of estrogen sensitive hypothalamic circuits. In a previous study, we demonstrated that GEN exposure through mothers resulted in an anxiolytic effect and a concurrent decrease of neural NO synthase (nNOS)+ cells in amygdale of male offspring [1]. This was consistent with both the role of NOS system in anxiety regulation and its sensitivity to gonadal hormones. In the present experiment, we analyzed anxiety levels and changes of neuronal circuits in mice directly fed with vehicle, Estradiol (E2) or GEN from birth (postnatal day 0, PND0) to PND8. Behavioral tests were conducted at PND60 and the mice were sacrificed at PND90. Coronal serial sections were processed for immunohistochemistry against nNOS and vasopressin (AVP). The GEN treatment had a dichotomic behavioral effects on sexes: anxiolitic on females while anxiogenic on males. Concurrently nNOS+ and AVP+ cell density in some hypothalamic nuclei was affected. Interestingly only a few of those effects were mimicked by E2 treatment suggesting that GEN may act trough different intracellular pathways.These results raise concerns about the possible long-term effects of soy-based food in livestock that largely use soy-based supplements and show hypo-fertility problems, as pigs. Similar concerns could involve the long-term use of soy-based formulas for babies

Genetic determinants in a critical domain of ns5a correlate with hepatocellular carcinoma in cirrhotic patients infected with hcv genotype 1b

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain‐1 interacts with cellular proteins inducing pro‐oncogenic pathways. Thus, we explore genetic variations in NS5A domain‐1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype‐1b infected DAA‐naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T (8.8% vs. 1.3%, p = 0.01), T122M (8.8% vs. 0.0%, p < 0.001), M133I (20.6% vs. 3.9%, p < 0.001), and Q181E (11.8% vs. 0.6%, p < 0.001). By multivariable analysis, the presence of >1 of them independently correlates with HCC (OR (95%CI): 21.8 (5.7–82.3); p < 0.001). Focusing on HCC‐group, the presence of these mutations correlates with higher viremia (median (IQR): 5.7 (5.4–6.2) log IU/mL vs. 5.3 (4.4–5.6) log IU/mL, p = 0.02) and lower ALT (35 (30–71) vs. 83 (48–108) U/L, p = 0.004), suggesting a role in enhancing viral fitness without affecting necroinflammation. Notably, these mutations reside in NS5A regions known to interact with cellular proteins crucial for cell‐cycle regulation (p53, p85‐PIK3, and β‐ catenin), and introduce additional phosphorylation sites, a phenomenon known to ameliorate NS5A interaction with cellular proteins. Overall, these results provide a focus for further investigations on molecular bases of HCV‐mediated oncogenesis. The role of these NS5A domain‐1 mutations in triggering pro‐oncogenic stimuli that can persist also despite achievement of sustained virological response deserves further investigation